Brands (R) sits alongisde PSV legend Marco van Bommel
The Dutchman is expected to take over the current position held by Steve Walsh.
Walsh is expected to be removed from his duties after a dire summer transfer window last year, which saw the club spend nearly £200 million on signings that largely disappointed.
“Marcel Brands has informed the supervisory board and his colleagues at PSV that he is leaving for Everton,” said a statement from PSV.
“The technical manager chooses for a new challenge in the Premier League after eight seasons in Eindhoven on June 1.”
Brands said: “It is a very difficult decision, but I think this is a good step at the right time.
“The Premier League is of course a great thing. It is the biggest competition in the world in all respects.
“I now get the chance to do something in my own way. I am really looking forward to that.”