The Real Madrid schemer has reportedly fallen out with under-fire boss Rafael Benitez after he was left out of the starting team for El Clasico, despite withdrawing from the Spain squad to prove his fitness.
His frustration was clear after he was sent off in the second half of the 4-0 defeat to Barcelona, prompting rumours he is unhappy with life in the Spanish capital.
And now, according to Tuttosport, Juve are readying a bid of around £28m for the 23-year-old.
Isco’s future at the Bernabeu has been uncertain since the arrival of Benitez last summer and he was linked with a move to Arsenal before the start of the season.
It now appears his time in Madrid is coming to an end with Juve set to provide an attractive career offer for the Spaniard.