1. David De Gea (goalkeeper) – see the full line up, in squad number order, by clicking the arrow above
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Wayne Rooney, Anthony Martial, Michael Carrick, Antonio Valencia and Marouane Fellaini are all sidelined through injury and illness, respectively.
Louis van Gaal will therefore have to make significant changes to his line up, and in particular may be forced to start the game without a recognise striker.
Will Memphis Depay, last season’s top scorer in the Dutch Eredivisie, be thrown back into the spotlight and take Rooney’s place up top?
Take a look at talkSPORT’s predicted line up by clicking the yellow arrow above, right.